Saturday, April 24, 2010

How does a phagocyte destroy bacteria?

first ift envelops the cell and then uses the organell called lysome to break it down

How does a phagocyte destroy bacteria?
Phagocytes destroy bacteria by engulfing them or eating them almost like how a amoeba eats. The Phagocyte will keep on engulfing bacteria until it explodes creating what we all know is pus.
Reply:It literally engulfs it, then using lysosomes with which specific enzymes breaks down the bacteria.
Reply:It attaches its self to its victim and then injects its own DNA into the bacteria. There has been some research into using bacterieaphages to combat infections such as mrsa and other bacterial infections but they have trouble in finding funding. The Japaneses were at the forefront of this when I was last looking into this type of subject. They have cultivated phages on human effluent. These were only effective on surface infections. Human immune systems kill off the phages internally and even on surface use they die off quickly.
Reply:Its a easy process in some steps: 1. Bacteria has a leucocute atracting substance (N Formilpeptide). 2. Phagocytes that are one of the first lines of defense (with neutrophyles) go to attack. 3. Phagocytes englobe bacteria and fuses with it (shallow it). 4. When bacteria is inside the phago, it fuses one of its organelles (lysosome) who contains digestive enzimes (lactoferrin, lysozin, peroxidase. etc) binds to it and digest the bacteria.


THis process is important bcause there is a congenital disease called glucose 6 phospate deshidrogenase deficiency (G6PDH) in which there is a inadecuate amounts of NADPH who is a metabolite needed by several enzimes, includes lysosyme for working. If you dont have this enzyme you will have, including other symptoms, a inmunodeficiency in the macrophages and this person will have recurrent infections of organism that are usually killed by macrophages like S. aureus, Klebsiella pneumoniae, etc
Reply:During phagocytosis the neutrophilic granules release digestive enzymes into the vacuole to kill or destroy the phagocytized particle or bacteria.
Reply:Engulfing the bacteria and release the enzyme lyso

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